abstract：:During the 6-year period from 1 October 1971 to 30 September 1977, 13 (about 1%) of 1225 admissions to hospital with asthma developed severe ventilatory failure (peak arterial PCO 2 greater than 8 kPa). Mean age was 4.1 years (2.3--7.9), and on average each patient had been admitted to hospital on 5 occasions during t...

journal_title：Archives of disease in childhood

authors： Simpson H,Mitchell I,Inglis JM,Grubb DJ

更新日期：1978-09-01 00:00:00

abstract：:After their first episode of febrile convulsions, 195 previously healthy children, aged 6--30 months, were given either diazepam or phenobarbitone for a year. Each child was assigned at random to one of the two medications: children admitted on even days were given a suppository containing 5 mg diazepam every 8 hours ...

journal_title：Archives of disease in childhood

authors： Knudsen FU,Vestermark S

更新日期：1978-08-01 00:00:00

abstract：:Of 80 children with proved coeliac disease, 2 presented with an associated disease of the distal portion of the large intestine. In one child the family history and the extension, localisation, and characteristics of intestinal lesions made us suspect ulcerative colitis; in the other we made a diagnosis of milk-induce...

journal_title：Archives of disease in childhood

authors： Ansaldi N,Santini B,Dell'olio D,Levis F

更新日期：1978-08-01 00:00:00

abstract：:We report a child who presented with a progressive neurological disorder associated with hypertension and paroxysms of irritability and sweating in whom an abnormality of catecholamine metabolism or excretion was demonstrated. An elder sister died at the age of 2 1/2 years with similar clinical symptoms but without bl...

journal_title：Archives of disease in childhood

authors： Young I,Hosking GP

更新日期：1978-08-01 00:00:00

abstract：:Lung function tests were carried out in the first 6 hours of life on 26 babies born by vaginal delivery and 10 born by caesarean section. The babies born by caesarean section had a mean thoracic gas volume of only 19.7 ml/kg body weight compared with 32.7 ml/kg for the babies born vaginally. We conclude that this is o...

journal_title：Archives of disease in childhood

authors： Milner AD,Saunders RA,Hopkin IE

更新日期：1978-07-01 00:00:00

abstract：:No consistent differences were found in mean heights and weights of 170 schoolchildren aged 6--12 years with the sickle cell trait and 1247 schoolchildren with normal haemoglobin living in Dominica and Jamaica. ...

journal_title：Archives of disease in childhood

authors： Ashcroft MT,Desai P,Grell GA,Serjeant BE,Serjeant GR

更新日期：1978-07-01 00:00:00

abstract：:A boy with fatal I-cell disease is reported. Defective ganglioside and glycoprotein metabolism is due to deficient neuraminidase activity. ...

journal_title：Archives of disease in childhood

authors： Milla PJ

更新日期：1978-06-01 00:00:00

abstract：:Thirty-two children with a past diagnosis of coeliac disease were reinvestigated by means of gluten challenge. They had received a gluten-free diet for a mean period of 6-5 years (range 0-25-11-0) before gluten challenge, and had a mean age of 9-9 years (range 3-0-15-3) at the onset of challenge. Small intestinal biop...

journal_title：Archives of disease in childhood

authors： Packer SM,Charlton V,Keeling JW,Risdon RA,Ogilvie D,Rowlatt RJ,Larcher VF,Harries JT

更新日期：1978-06-01 00:00:00

abstract：:Seventy-three low birthweight babies were independently assessed for gestational age using the scoring system of Dubowitz et al. (1970) and 5 neurological reflexes described by Robinson (1966). The results obtained by the 5 reflexes were compared with those obtained by the scoring system and were found to be accurate ...

journal_title：Archives of disease in childhood

authors： Serfontein GL,Jaroszewicz AM

更新日期：1978-06-01 00:00:00

abstract：:Serial small intestinal biopsies related to withdrawal and challenge with cows' milk are described in 5 infants with cows' milk protein intolerenace. On the basis of these serial observations the existence of a cows' milk-sensitive enteropathy in infancy is clearly established. The cows' milk-sensitive mucosal lesion ...

journal_title：Archives of disease in childhood

authors： Walker-Smith J,Harrison M,Kilby A,Phillips A,France N

更新日期：1978-05-01 00:00:00

abstract：:In a newborn baby, suffering from persistent severe hypoglycaemia with convulsions glucagon deficiency was shown. Treatment with zinc-protamine-glucagon injection twice daily resulted in normal blood glucose levels. Motor development is delayed. ...

journal_title：Archives of disease in childhood

authors： Kollee LA,Monnens LA,Cecjka V,Wilms RM

更新日期：1978-05-01 00:00:00

abstract：:A combined test of anterior pituitary function was used on 21 normal children. It shows that a comprehensive evaluation can be made of growth hormone, thyroid stimulating hormone, adrenocorticotrophic hormone, and gonadotrophin reserve. Simultaneous assessment of those peripheral glands associated with the anterior pi...

journal_title：Archives of disease in childhood

authors： Savage DC,Swift PG,Johnston PG,Goldie DJ,Murphy D

更新日期：1978-04-01 00:00:00

abstract：:A 32-day-old male infant had hypocalcaemic convulsions associated with asymptomatic maternal hyperparathyroidism. Very low total and ionised serum calcium, increased serum phosphate, and normal serum parathyroid hormone (PTH) and 25-hydroxycholecalciferol (25-OHD3) concentrations were found at admission. After treatme...

journal_title：Archives of disease in childhood

authors： Jacobsen BB,Terslev E,Lund B,Sørensen OH

更新日期：1978-04-01 00:00:00

abstract：:Hair growth measurements are a sensitive indicator of nutrition and we have assessed their value in the perinatal period. The proportion of growing roots and their diameter were studied at birth in 114 babies and repeated 3 weeks later in 29 low birthweight babies. Intrauterine malnutrition resulted in thinner roots b...

journal_title：Archives of disease in childhood

authors： Berger HM,King J,Doughty S,Wharton BA

更新日期：1978-04-01 00:00:00

abstract：:Adrenal cortical carcinoma in a 4 1/4-month-old girl was treated by surgery in combination with actinomycin D, cyclophosphamide, and 5-fluorouracil given daily for 5 days every third week for 13 1/2 months. Postoperative hypertension and raised 24-hour 17-hydroxy- and 21-oxosteroids suggested residual microscopical tu...

journal_title：Archives of disease in childhood

authors： Visconti EB,Peters RW,Cangir A,Zorn GL Jr,Fisher S

更新日期：1978-04-01 00:00:00

abstract：:A review of 105 children with urinary tract infection showed an increasing prevalence of grades II-III vesicoureteric reflux with diminishing age. During infancy reflux was almost always severe, and affected boys as often as girls. Radiologically scarred kidneys were drained by refluxing ureters in 98% of cases. The p...

journal_title：Archives of disease in childhood

authors： Shah KJ,Robins DG,White RH

更新日期：1978-03-01 00:00:00

abstract：:Two newborn infants, male (A) and female (B), with lethal hyperammonaemia are described in the same family. In both, symptoms started on the second day of life. Lethargy and hypotonia were the most prominent initial findings and were followed by convulsions and coma. In both, blood ammonia levels rose to 570 mumol/u (...

journal_title：Archives of disease in childhood

authors： Mantagos S,Tsagaraki S,Burgess EA,Oberholzer V,Palmer T,Sacks J,Baibas S,Valaes T

更新日期：1978-03-01 00:00:00

abstract：:Three cases are reported in which thrombi were found in the aorta at postmortem. In each case the thrombus had originated within the ductus arteriosus. We believe that in recent years the attention paid to the presence of indwelling cannulae as a cause of embolic phenomena in the newborn period has led to a reduction ...

journal_title：Archives of disease in childhood

authors： Knowlson GT,Marsden HB

更新日期：1978-02-01 00:00:00

abstract：:The fall in body temperature that occurs in babies soon after birth is influenced by the baby's weight and its environmental conditions. The rate of oxygen consumption 1 1/2 hours after birth was unrelated to body temperature and only slightly raised, indicating a limited thermogenic capacity. A radiant heater effecti...

journal_title：Archives of disease in childhood

authors： Smales OR,Kime R

更新日期：1978-01-01 00:00:00

abstract：:Endotracheal intubation and intermittent positive pressure ventilation were used to overcome the difficulties of oxygen therapy for pneumatosis cystoides coli in a 9-year-old child with Down's syndrome and a congenital heart defect. As compared to previously reported cases, a shorter duration of treatment and a lower ...

journal_title：Archives of disease in childhood

authors： Mackinnon AE,Frank JD,Morris P

更新日期：1977-12-01 00:00:00

abstract：:The clinical, radiological, and biochemical features of 2 male children with mannosidosis are described. Superficially they appeared to suffer from Hurler's syndrome, but the facies, eye signs, radiological and cytological features were atypical. Excess urinary oligosaccharides were found by thin-layer chromatography....

journal_title：Archives of disease in childhood

authors： Milla PJ,Black IE,Patrick AD,Hugh-Jones K,Oberholzer V

更新日期：1977-12-01 00:00:00

abstract：:Sixteen children who had had congenital diaphragmatic herniae repaired either in the neonatal period (11), or in early childhood (5), were reviewed at between 7 and 19 years of age. Only minor abnormalities were shown in their chest x-rays and in a variety of lung function tests. This suggests that the long-term progn...

journal_title：Archives of disease in childhood

authors： Kerr AA

更新日期：1977-11-01 00:00:00

abstract：:A child with chronic diarrhoea since birth responded to the prostaglandin synthetase inhibitors aspirin and indomethacin. During a period without treatment, raised levels of prostaglandins F2alpha and E2 were observed. No source for these raised prostaglandins was shown, and it is suggested that she may have an inborn...

journal_title：Archives of disease in childhood

authors： Dodge JA,Hamdi I,Walker S

更新日期：1977-10-01 00:00:00

abstract：:An increased incidence of E. coli sepsis has been observed in neonates given intramuscular iron-dextran for prevention of iron deficiency. Mechanisms for this apparent effect on susceptibility to infection were investigated by comparing phagocytic and antibacterial functions in paired samples of venous blood from 7 in...

journal_title：Archives of disease in childhood

authors： Becroft DM,Dix MR,Farmer K

更新日期：1977-10-01 00:00:00

abstract：:A survey of 158 children with acute haematogenous osteomyelitis, and of 94 children with acute septic arthritis over an 8-year period was made to determine which bacteria cause these infections. In the osteomyelitis group the organism most frequently detected was Staphylococcus aureus (74% of cases). In 16% of cases s...

journal_title：Archives of disease in childhood

authors： Nade S

更新日期：1977-09-01 00:00:00

abstract：:The use of the Bene-Anthony Family Relations Test is described and illustrated by three examples of child abuse. This test should be considered in the investigation of definite or suspected cases of abuse and as part of the preparation of court evidence. ...

journal_title：Archives of disease in childhood

authors： Geddis DC,Turner IF,Eardley J

更新日期：1977-09-01 00:00:00

abstract：:Eighty-two cases of protracted diarrhoea in infancy presenting over a 6-year period have been analysed, with particular reference to diagnosis and management. The patients fell into 1 of 2 categories according to whether a specific diagnosis was established or not. A diagnosis (category 1) was established in 59 (72%),...

journal_title：Archives of disease in childhood

authors： Larcher VF,Shepherd R,Francis DE,Harries JT

更新日期：1977-08-01 00:00:00

abstract：:Pethidine or an epidural injection of bupivacaine are common forms of obstetric analgesia in Britain. Bupivacaine has been thought to have little effect on the fetus, but neurobehavioural studies have cast doubt on this. We therefore investigated the elimination of these drugs by babies in similar population groups. B...

journal_title：Archives of disease in childhood

authors： Cooper LV,Stephen GW,Aggett PJ

更新日期：1977-08-01 00:00:00

abstract：:Two infants presented with a salt-losing syndrome, the presenting features of which were subtle. One case appeared to be transient. Deficient production of aldosterone was shown by plasma renin activity and plasma aldosterone profile. Gas chromatography-mass spectrometry of urine indicated a defect in 18-dehydrogenati...

journal_title：Archives of disease in childhood

authors： Milla PJ,Trompeter R,Dillon MJ,Robins D,Shackleton C

更新日期：1977-07-01 00:00:00

abstract：:Among 40 hospitalized infants and children with cytomegalovirus infection, 14 (35%) had interstitial pneumonitis, 4 (10%) had wheezing or tachypnoea but without x-ray evidence of classical interstitial pneumonia, the remaining 22 (55%) were free of pulmonary involvement. Most patients had tachypnoea and nonproductive ...

journal_title：Archives of disease in childhood

authors： Smith SD,Cho CT,Brahmacupta N,Lenahan MF

更新日期：1977-06-01 00:00:00

abstract：:To use a combined single document clinical case sheet/computer record which can form the basic document for a life medical record is a practical proposition. With adequate briefing doctors and nurses soon become familiar with the record and appreciate its value. Secretarial and clerical requirements are reduced to a m...

journal_title：Archives of disease in childhood

authors： Walker CH

更新日期：1977-06-01 00:00:00

abstract：:Serum antitoxoplasma titres were determined simultaneously by the direct agglutination and the indirect immunofluorescent tests in 52 children aged 2 to 16 years having chronic lymph node enlargement, mainly cervical. Direct agglutination titres were raised (64 to 4096) in 22 children (42%), but rarely in the control ...

journal_title：Archives of disease in childhood

authors： Thomaidis T,Anastassea-Vlachou K,Mandalenaki-Lambrou C,Theodoridis C,Vrahnou E

更新日期：1977-05-01 00:00:00

abstract：:The effect of phototherapy on plasma cyclic-AMP in newborn infants has been studied. Our results suggest that phototherapy does not produce appreciable changes in plasma cyclic-AMP levels. ...

journal_title：Archives of disease in childhood

authors： Constantopoulos A,Karaboula K,Matsaniotis N

更新日期：1977-05-01 00:00:00

abstract：:A retrospective study was made of 30 children with Leber's amaurosis (congenital retinal blindness). 24 presented with severe visual impairment, typical ophalmological findings, and absent electroretinograms. 6 other children, though presenting with marked visual loss and absent electroetinograms were later shown to b...

journal_title：Archives of disease in childhood

authors： Vaizey MJ,Sanders MD,Wybar KC,Wilson J

更新日期：1977-05-01 00:00:00

abstract：:Eighteen children with pneumocystis carinii pneumonia diagnosed over a period of 16 years at a children's hospital are reviewed. All had an underlying disease, either congenital immunodeficiency or a malignancy. 15 patients were treated, 10 with pentamidine isethionate alone, 2 with both pentamidine and co-trimoxazole...

journal_title：Archives of disease in childhood

authors： Lipson A,Marshall WC,Hayward AR

更新日期：1977-04-01 00:00:00

abstract：:Twenty-one children who had been diagnosed as having laryngomalacia by direct laryngoscopy in infancy were reviewed 7 to 12 years later. The natural history of the disease is documented. A wide variation in the time of onset and duration of the stridor was found and there was a high incidence of feeding difficulties. ...

journal_title：Archives of disease in childhood

authors： McSwiney PF,Cavanagh NP,Languth P

更新日期：1977-03-01 00:00:00

abstract：:We studied 91 offspring of ABO incompatible preganacies and 30 controls resulting from O--O pregnancies to test whether cord bilirubin levels could be used to predict the severity of hyperbilirubinaemia in ABO incompatibility. Blood group, direct Coombs's test, and serum bilirubin estimations were carried out on cord ...

journal_title：Archives of disease in childhood

authors： Risemberg HM,Mazzi E,MacDonald MG,Peralta M,Heldrich F

更新日期：1977-03-01 00:00:00

abstract：:Pyogenic meningitis occurred in 6 infants in the course of chronic gastroenteritis, in 5 of whom a normal CSF had been recorded earlier in the illness. Clinical signs of meningitis were often absent. The problems of diagnosis and management and of possible predisposition to pneumococcal meningitis in children sufferin...

journal_title：Archives of disease in childhood

authors： Wyatt GP,Marcus JC

更新日期：1977-02-01 00:00:00

abstract：:Growth velocity of head circumference was studied longitudinally in different gestational age groups of 222 appropriate-weight-for-dates (AFD) and 94 small-for-dates (SFD) healthy infants during the first 5 months of life. Term AFD and SFD infants showed a steady slowing of growth rate of head circumference from birth...

journal_title：Archives of disease in childhood

authors： Fujimura M,Seryu JI

更新日期：1977-02-01 00:00:00

abstract：:A quantitative morphological assessment was carried out of the cellularity and staining properties of the cells of the layers of the human cerebellar cortex, both in the normal child and in 41 children suffering from a series of disorders including mental retardation. A computerized image analyser and highly standardi...

journal_title：Archives of disease in childhood

authors： Gadson DR,Emery JL

更新日期：1976-12-01 00:00:00